Follow Your Nose: Axon Pathfinding in Olfactory Map Formation
نویسندگان
چکیده
منابع مشابه
Follow Your Nose: Axon Pathfinding in Olfactory Map Formation
Two new studies report how discrete identities of olfactory sensory neurons are converted into a spatial map of axonal connections (Imai et al., 2006; Serizawa et al., 2006). They find that levels of cAMP signals derived from olfactory receptors (ORs) can direct targeting of axons along an axis, and that ORs and neural activity regulate expression of adhesion/guidance molecules in mosaic patter...
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The convergence of olfactory axons expressing particular odorant receptor (Or) genes on spatially invariant glomeruli in the brain is one of the most dramatic examples of precise axon targeting in developmental neurobiology. The cellular and molecular mechanisms by which olfactory axons pathfind to their targets are poorly understood. We report here that the SH2/SH3 adapter Dock and the serine/...
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During the development of the nervous system, neurons often connect axons and dendrites over long distances, which are navigated by chemical cues. During the past few decades, studies on axon guidance have focused on chemical cues provided by the axonal target or intermediate target. However, recent studies have shed light on the roles and mechanisms underlying axon-axon interactions during neu...
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The organization of representations in the brain has been observed to locally reflect subspaces of inputs that are relevant to behavioral or perceptual feature combinations, such as in areas receptive to lower and higher-order features in the visual system. The early olfactory system developed highly plastic mechanisms and convergent evidence indicates that projections from primary neurons conv...
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Timothy R. Henion,1,2 Denitza Raitcheva,1 Robert Grosholz,1 Franziska Biellmann,3 William C. Skarnes,4 Thierry Hennet,3 and Gerald A. Schwarting1,2 1Shriver Center, Waltham, Massachusetts 02452, 2Department of Cell Biology, University of Massachusetts Medical Center, Worcester, Massachusetts 01655, 3Institute of Physiology, University of Zurich, CH-8057 Zurich, Switzerland, and 4Wellcome Trust ...
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ژورنال
عنوان ژورنال: Cell
سال: 2006
ISSN: 0092-8674
DOI: 10.1016/j.cell.2006.11.017